Introduction Animal experiments are one way in which men make use of animals, but, unlike mass breeding, killing of livestock or fur-bearing animals and pest control, animal experiments have become in recent years a focus of public comment and criticism. https://www.regjeringen.no/en/ dokumenter/gene-technology-act/id173031/, The Animal Welfare Act. Ethical self-examination involves a careful … h��Y]o7�+��f��3@ �Vb�'�2,� �amM|{�w�����+rj�+�Z-�Kr@lr8�"����m��Z�:'�w�w��]�:ߛ��b�x�MN�U��6$��t��o� In modern times, th… Justification of study and use of animals, training of personnel, care of animals during and after the study, ethically obtaining the subjects. These guidelines provide a framework that also covers ethical questions associated with the use of genetically modified animals in research. [1] The Norwegian National Committee for Research Ethics in Science and Technology (NENT). A researcher's assessment of what is considered acceptable suffering shouldbe based on the animals that suffer the most. Transparency is also important in order to ensure that the public are informed and is part of researchers' responsibility for dissemination. Each country recognizes modern society's ethical concerns over the use of animals in research and each has developed their own regulatory framework to support the humane care and use of laboratory animals. These committees are variously referred to as Animal Care Committees, Institutional Animal Care and Use Committees, and Animal Ethics Committees. (Gene Technology Act) (Lov om framstilling og bruk av genmodifiserte organismer m.m. They are also intended to contribute to reflection on research ethics and the use of animals in research in both research communities and in the public debate. Applied Animal Behaviour Science, 81: 291-305. As Chair of the Working Group, I would like to record my thanks to all members, who have The first sentence of the Guide for the Care and Use of Laboratory Animals (Guide 1), which institutions covered by PHS rules must consult, proclaims an ethical principle intended to underlie the Guide's recommendations: “all who care for or use animals in research, teaching, or testing must assume responsibility for their well-being” ( NRC 1996, p 1). This is the background for the current guidelines. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Jul-Aug 2016;20(4):360-368. doi: 10.4103/0972-124X.186931. 2003.https://lovdata.no/dokument/LTI/forskrift/2003-03-14-349, Regulation on Animal Experimentation (Forskrift om bruk av dyr i forsøk). Disclosing negative results may give other researchers information about which experiments are not worth pursuing, shine a light on unfortunate research design, and help reduce the use of animals in research. It is generally thought that it may be necessary to use laboratory animals in some cases in order to create improvements for people, animals or the environment. Ethical Guidelines, Animal Profile, Various Animal Models Used in Periodontal Research With Alternatives and Future Perspectives J Indian Soc Periodontol. 1. Researchers must have respect for animals' worth, regardless of their utility value, and for animals' interests as living, sentient creatures. If there are any doubts regarding perceived suffering, consideration of the animals must be the deciding factor. Overview of the current regulatory testing requirements for medicinal products for human use and opportunities for implementation of the 3Rs When there is credible, but uncertain, knowledge that the inclusion of animals in research or the use of certain methods may have ethically unacceptable consequences for the stock and the ecosystem as a whole, researchers must observe the precautionary principle.[1]. Researchers must minimise the risk of suffering and provide good animal welfare. �Y�� The following guidelines were developed by the American Psychological Association (APA) for use by psychologists working with nonhuman animals. Ethics is a critical reflection on how we should act and why. It provides a framework for deciding whether animal use can be justified within each scientific project, taking into account animal welfare, scientific and ethical issues. Suffering can only be caused to animals if this is counterbalanced by a substantial and probable benefit for animals, people or the environment. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) are a checklist of recommendations to improve the reporting of research involving animals – maximising the quality and reliability of published research, and enabling others to … The ethical assessments related to the use of animals in research are wide-ranging. Given by the National Committee for Research Ethics in Science and Technology (NENT), 2018. 482 0 obj <>stream Researchers are responsible for considering whether it is possible to reduce the number of animals the experiment plans to use and must only include the number necessary to maintain the scientific quality of theexperiments and the relevance of the results. The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. If no good options are available, researchers should consider whether the research can be postponed until alternative methods have been developed. It considers the ethical issues of research involving animals in the light of these developments, the implications for regulation, and the provision of information and education. These principles also state what can reasonably be considered harm and benefit, and the principles thus facilitate good assessments. Research institutions should provide training on suitable models, and researchers are responsible for using such methods of analysis when planning experiments on animals. Procurement of animals 12 7. NENT's role in following up the guidelines is to provide advice and recommendations, help increase awareness of animal welfare, and to stimulate continued discussion about research that involves animals. Describe three ethical guidelines that researchers must follow when conducting research with non-human animal subjects. The Ethics Committee for Animal Experimentation of both Academies revised the Ethical Principles and Guidelines for Animal Testing in the light of recent experience and insights in 1993 and 2005. of animals including the uses being made of these new advances. Genetically modifying laboratory animals, i.e. ETHICAL STANDARDS AND GUIDELINES FOR ANIMAL EXPERIMENTS IN TOXINOLOGICAL RESEARCH 1. This version of the Ethical Principles and Guidelines for Experiments on Animals was approved by the Senate of the The guidelines will be useful when planning projects, assessing them, and when reporting and publishing findings and results. Regulated laboratory procedures 9 6. 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